Two main reasons may be given of it, why students should be more subject to this malady [melancholy] than others. The one is, they live a sedentary, solitary life, sibi et musis, free from bodily exercise, and those ordinary disports which other men use: and many times if discontent and idleness concur with it, which is too frequent, they are precipitated into this gulf on a sudden: but the common cause is overmuch study; too much learning (as Festus told Paul) hath made thee mad; ’tis that other extreme which effects it.

SUBSECT. XV.– Love of Learning, or overmuch study. With a Digression on the misery of Scholars, and why the Muses are Melancholy.

The Anatomy of Melancholy
Robert Burton