Aggression, also found in the majority of neurotic states and in certain psychoses, can be connected with the passion of anger in the broader sense given to this term by the Fathers. Asthenia or lethargy, common to many mental diseases, corresponds rather exactly to one of the essential components of the passion of acedia. One can also perceive a direct connection between standard neurotic phobias, defined as ‘agonizing fears, with the passion of fear. The neurosis of anxiety can be easily classified within the framework of this same passion of fear and the passion of sadness. Psychotic depression has a connection on the one hand with acedia and on the other with despair, an extreme form of the passion of sadness.

Mental Disorders & Spiritual Healing: Teachings from the Early Christian East 
Jean-Claude Larchet