Give me any instance then of a man as wise as you can fancy him possible to be, that has spent all his younger years in poring upon books, and trudging after learning, in the pursuit whereof he squanders away the pleasantest time of his life in watching, sweat, and fasting; and in his latter days he never tastes one mouthful of delight, but is always stingy, poor, dejected, melancholy, burthensome to himself, and unwelcome to others, pale, lean, thin-jawed, sickly, contracting by his sedentariness such hurtful distempers as bring him to an untimely death, like roses plucked before they shatter. Thus have you, the draught of a wise man’s happiness, more the object of a commiserating pity, than of an ambitioning envy.

In Praise of Folly
Erasmus